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Table of Contents
CASE REPORT
Year : 2019  |  Volume : 5  |  Issue : 3  |  Page : 106-108

Thrombus on the device early after the procedure of the left atrial appendage closure with the amplatzer cardiac plug: Is something wrong with the procedure or the device?


Department of Cardiology, S.B.U Izmir Tepecik Research Hospital, Izmir, Turkey

Date of Submission22-Dec-2018
Date of Decision18-Jan-2019
Date of Acceptance23-Apr-2019
Date of Web Publication22-Jul-2019

Correspondence Address:
Dr. Baris Kilicaslan
Department of Cardiology, S.B.U Izmir Tepecik EAH, Güney Mahallesi, 1140/1, Sokak No: 1, Yenişehir - Konak - Izmir
Turkey
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/IJCA.IJCA_54_18

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  Abstract 


Percutaneous left atrial appendage (LAA) closure is a currently utilized procedure for the prophylaxis of thromboembolic cerebrovascular events in selected patients with nonvalvular atrial fibrillation. The presence of thrombus on closure device was reported at 1st and 3rd months after the procedure, but as far as our knowledge, there are no data about early thrombus formation on the device during procedure. We present a case demonstrating thrombus on the atrial side of the Amplatzer Amulet LAA occluder device early after the implantation.

Keywords: Atrial fibrillation, sol atrial appendage, stroke


How to cite this article:
Kilicaslan B, Ozdogan O, Cabuk AK, Mutlu I. Thrombus on the device early after the procedure of the left atrial appendage closure with the amplatzer cardiac plug: Is something wrong with the procedure or the device?. Int J Cardiovasc Acad 2019;5:106-8

How to cite this URL:
Kilicaslan B, Ozdogan O, Cabuk AK, Mutlu I. Thrombus on the device early after the procedure of the left atrial appendage closure with the amplatzer cardiac plug: Is something wrong with the procedure or the device?. Int J Cardiovasc Acad [serial online] 2019 [cited 2019 Aug 23];5:106-8. Available from: http://www.ijcva.com/text.asp?2019/5/3/106/263080




  Introduction Top


Today, with an aging population, atrial fibrillation (AF) is more common and has an increased risk of embolic cerebrovascular accidents. Anticoagulation strategies alone are not sufficient, and as a large proportion of the thrombus involved in these cerebrovascular accidents are seen to arise from the left atrial appendage (LAA). Device closure of the LAA is a nonpharmacologic approach to stroke prevention in AF patients. We present a case with an early thrombotic complication during LAA closure which was successfully treated.


  Case Report Top


A physically active 76-year-old female with persistent AF was referred for the LAA occlusion because of recurrent cerebral stroke, under anticoagulant therapy with warfarin and afterward with dabigatran 150 mg bid. The patient's CHADS-VASc score was 5 and HAS-BLED score was 3. After a multidisciplinary interrogation (neurologist, cardiologist, and radiologist), the cerebral stroke was attributed to thromboembolization secondary to AF and percutaneous LAA closure was planned. The patient's eligibility for treatment with the Amplatzer Amulet device was determined by cardiac computed tomography angiography and transesophageal echocardiography (TEE). The procedure was performed under general anesthesia, TEE, and fluoroscopic guidance. Transseptal access was achieved through the right femoral vein, using an SL1 sheath and a BRK-1 needle (St. Jude Medical, MN, USA). Intravenous heparin was given with a target activated clotting time >300s. An extra-stiff wire was advanced through the upper pulmonary vein, and then, we inserted a 14 F guiding sheath through the wire. Then, we inserted a 22 no device through the catheter, and we pulled back all system from the pulmonary vein and directed to the LAA ostium. We rotated the system counter-clockwise and positioned it into the LAA. We checked its position with fluoroscopy, two-dimensional (2D) and three-dimensional (3D) TEE. After we released the device, we recognized a linear thrombus on the atrial side of the device with 2D and 3D echocardiography [Figure 1] and [Figure 2]. We pulled back the catheter and there was a big linear thrombus on the distal tip of the catheter [Figure 3]. The activated clotting time (ACT) was 290 s at that time. We injected 5000 U unfractionated heparin (UFH) (intravenous) bolus after the procedure and continued with infusion at a rate of 1000 U/h for 48 h (dosage titrated according to activated partial thromboplastin time). After the infusion we performed TEE again and the thrombus had successfully been dissolved [Figure 4]. The patient was discharged with clopidogrel 75 mg 1 × 1 and acetylsalicylic acid 100 mg 1 × 1. One month after this procedure, TEE confirmed a good position of the device without thrombus [Figure 5].
Figure 1: 2D views of the thrombus on the device

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Figure 2: 3D views of the thrombus on the device

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Figure 3: Thrombus on the tip of the catheter

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Figure 4: 2D view of the device after heparin infusion

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Figure 5: 3D view of the device after heparin infusion

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  Discussion Top


In the literature, thrombus formation on the device was demonstrated at the 1st and 3rd months after the procedure.[1],[2] However, there are no data about thrombus formation early after percutaneous LAA closure. Screw area of the device could be a progenitor of thrombus formation so we should be aware of giving effective dosage of UFH and obtaining at least 300s of ACT level during operation. Wolff et al.[3] recently reported two cases with early thrombus formation during Mitraclip procedure which were successfully treated with low dose thrombolytic infusion and with no embolic complication, but data about this kind of therapy particularly thrombi in the left side of the heart insufficient for us; hence, we choose the safer way.


  Conclusion Top


This case demonstrates a management option of early thrombotic complication during LAA closure.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Sedaghat A, Schrickel JW, Andrié R, Schueler R, Nickenig G, Hammerstingl C, et al. Thrombus formation after left atrial appendage occlusion with the amplatzer amulet device. JACC Clin Electrophysiol 2017;3:71-5.  Back to cited text no. 1
    
2.
Landmesser U, Tondo C, Camm J, Diener HC, Paul V, Schmidt B, et al. Left atrial appendage occlusion with the AMPLATZER amulet device: One-year follow-up from the prospective global amulet observational registry. EuroIntervention 2018;14:e590-7.  Back to cited text no. 2
    
3.
Wolff G, Kelm M, Westenfeld R, Horn P. Low-dose thrombolysis for the management of left atrial thrombus formation during percutaneous mitral valve repair. JACC Cardiovasc Interv 2019;12:e9-10.  Back to cited text no. 3
    


    Figures

  [Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5]



 

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