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Year : 2020  |  Volume : 6  |  Issue : 3  |  Page : 106-109

Correlation of optical coherence tomography-derived variables with fractional flow reserve (≤0.8) in patients with coronary artery stenosis: An observational study

1 Department of Cardiology, Shree Sant Acchyut Maharaj Heart Hospital, Amravati, Maharastra, India
2 Department of Cardiology, Army Hospital Research and Referral, New Delhi, India

Correspondence Address:
Dr. Nitin Sonune
Shree Sant Acchyut Maharaj Heart Hospital, Amravati - 444 602, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/IJCA.IJCA_23_20

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Objective: The present study was designed to establish the correlation between anatomical variables analyzed using optical coherence tomography (OCT) and physiological assessment provided by fractional flow reserve (FFR, ≤0.8) in patients with significant coronary artery stenosis. Materials and Methods: This was a prospective, single-center observation study which included total fifty patients who were diagnosed with coronary artery disease in the presence of significant stenosis (>70%) as per coronary angiography. The FFR ≤0.8 was considered as positive with severe stenosis. Minimal luminal area (MLA), minimal luminal diameter (MLD), percent area stenosis, and percent diameter stenosis were calculated as OCT variables in all patients. Results: The mean age of the patients was 56 ± 7.13 years. The mean FFR was found to be 0.72 ± 0.06. The OCT-derived MLA was 1.97 ± 0.53 mm2 and MLD was 1.35 ± 0.22 mm. The Pearson correlation coefficients of OCT-derived MLA (cutoff: 2 mm2) and MLD (cutoff: 1.24 mm) with FFR were 0.21 (P < 0.05) and 0.03 (P < 0.05) with 67% and 71% diagnostic efficiency, respectively. Conclusion: The study identified a significant correlation between OCT-derived MLA (poor)/MLD (moderate) and FFR (≤0.8). Thus, both the techniques, when performed collectively, provide valuable information regarding coronary artery morphology and physiology.

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