|Year : 2020 | Volume
| Issue : 3 | Page : 124-128
Relationship between CHA2DS2-VASc score and echocardiography parameters with ischemic stroke development
Kerem Can Yilmaz, Orcun Ciftci, Kaan Okyay, Serpil Eroglu, Bahar Pirat, Elif Sade, Melek Ulucam, Bulent Ozin, Haldun Muderrisoglu
Department of Cardiology, Baskent University School of Medicine, Ankara, Turkey
|Date of Submission||17-Apr-2020|
|Date of Decision||25-May-2020|
|Date of Acceptance||24-Jun-2020|
|Date of Web Publication||28-Sep-2020|
Dr. Kerem Can Yilmaz
Department of Cardiology, Baskent University School of Medicine, Ankara
Source of Support: None, Conflict of Interest: None
Context: Atrial fibrillation (AF) is the most common persistent rhythm disorder that has been shown to be associated with a significant increase in stroke risk. CHA2DS2-VASc is a scoring system to identify the risk of thromboembolism in nonvalvular AF patients. Aims: The aim of our study was to investigate the relationship between the demographic properties, transthoracic and transesophageal echocardiography parameters, the patients' CHA2DS2-VASc scores, and cerebrovascular events. Subjects and Methods: There were 48 patients with previous stroke and 217 patients without. We compared patients' demographic data, echocardiographic parameters, presence of patent foramen ovale (PFO) in transesophageal echocardiography, medications, AF categories, and CHA2DS2-VASc scores. Results: The mean age of the stroke group was 64.8 ± 12.3 years; the mean age of the control group was 63.2 ± 12.8 years (P = 0.417). The CHA2DS2-VASc score was 3.25 ± 2.06 in the stroke group and 2.49 ± 1.54 in the nonstroke group (P < 0.001). As for the presence of PFO, it was present in 45.8% of patients who had a stroke, but only 17.9% in the nonstroke group (P < 0.001). Conclusions: CHA2DS2-VASc score increases the risk of stroke in a broader sense, but not only in patients with AF. It is reasonable to think that the higher the score, the higher the risk of stroke. Furthermore, the presence of PFO in a patient is a facilitating factor for stroke, which may be considered for closure in the case of recurrent stroke episodes.
Keywords: Anticoagulants, atrial fibrillation, stroke, thrombus
|How to cite this article:|
Yilmaz KC, Ciftci O, Okyay K, Eroglu S, Pirat B, Sade E, Ulucam M, Ozin B, Muderrisoglu H. Relationship between CHA2DS2-VASc score and echocardiography parameters with ischemic stroke development. Int J Cardiovasc Acad 2020;6:124-8
|How to cite this URL:|
Yilmaz KC, Ciftci O, Okyay K, Eroglu S, Pirat B, Sade E, Ulucam M, Ozin B, Muderrisoglu H. Relationship between CHA2DS2-VASc score and echocardiography parameters with ischemic stroke development. Int J Cardiovasc Acad [serial online] 2020 [cited 2020 Oct 27];6:124-8. Available from: https://www.ijcva.com/text.asp?2020/6/3/124/296231
| Introduction|| |
Atrial fibrillation (AF) is the most common persistent rhythm disorder that has been shown to be associated with a significant increase in stroke risk. Left atrial appendage (LAA) thrombi are responsible for most strokes of cardiac origin. CHA2 DS2-VASc is a scoring system to identify the risk of thromboembolism and thus the indications for anticoagulation in nonvalvular AF patients. CHA2 DS2-VASc score ranges from 0 to 9 points, where congestive heart failure or left ventricular ejection fraction (EF) ≤0.40, hypertension, age 65–74 years, diabetes mellitus, vascular disease, and female sex are each assigned 1 point; age ≥75 years, prior stroke, transient ischemic attack, and thromboembolism are each assigned 2 points. Anticoagulation is recommended in patients with a CHA2 DS2-VASc score of 2 and above. In addition, patent foramen ovale (PFO) is detected in some patients with cryptogenic stroke. PFO prevalence is 6 times greater in cryptogenic stroke under the age of 55 than other causes of stroke. PFO is a defect located at the interatrial septum that provides right-to-left shunt in fetal circulation and persists after birth in 27% of the general population. Paradoxical embolism through a PFO generally originates from deep vein thrombosis, although air, amniotic fluid, and fat embolism may rarely cause a stroke by right-to-left shunting, especially during a Valsalva maneuver.
The aim of our study was to investigate the relationship between the demographic properties, the presence of left atrial thrombus, and the presence of PFO in patients undergoing transesophageal echocardiography (TEE); we also aimed to examine the relationship between the patients' CHA2 DS2-VASc scores and cerebrovascular events.
| Subjects and Methods|| |
This study enrolled a total of 265 patients who were admitted to our adult cardiology outpatient clinic and who underwent TEE procedure for any indication between June 2017 and June 2019. Patient's demographic data, transthoracic and transesophageal echocardiographic examinations, and laboratory test results were recorded retrospectively. Patients with missing medical data, cancer with ongoing treatment, hematological thrombotic disorders, and catheter thrombus surveilled by successive TEE examinations were excluded.
The patients were divided into two groups according to their previous stroke. There were 48 patients with previous stroke specified as Group I and 217 patients without stroke specified as Group II. We compared patient's demographic data, echocardiographic parameters, presence of PFO in TEE, medications, AF categories, and CHA2 DS2-VASc scores.
AF was categorized on the basis of patient history and ESC AF Guidelines. Accordingly, paroxysmal AF was defined by symptoms lasting up to 7 days, persistent AF between 7 days and 1 year, long-standing persistent AF more than 1 year, and permanent AF for an undetermined period of time. Newly diagnosed AF was diagnosed by a new onset of symptoms and the absence of any previous history of AF.
For all patients, hemoglobin, hematocrit, white blood cell count, platelet count, creatinine, high-density lipoprotein, triglyceride, and low-density lipoprotein levels were recorded. Study protocols approved by the local ethics committee were utilized throughout the study. A standardized questionnaire was used to collect clinical and demographic information, including medication history.
Laboratory data and echocardiographic variables were compared between the two groups using Kruskal–Wallis test, with paired Mann–Whitney U-test being performed as the post hoc analysis to identify significantly different pairs. Categorical data were analyzed with the Fisher's exact test and Chi-squared test. Normally distributed continuous variables were expressed as the mean ± standard deviation; nonnormally distributed continuous variables were expressed as median (minimum–maximum); and categorical variables were presented as percentage (%). Backward stepwise logistic regression analysis method was used for multivariate analysis. P < 0.05 was considered statistically significant. All analyses were performed using the SPSS statistical software package (version 25; SPPS, Chicago, IL, USA).
| Results|| |
The mean age of the Group I was 64.8 ± 12.3 years; the mean age of the Group II was 63.2 ± 12.8 years (P = 0.417). The percentage of men was 64.5% in Group I and 62.2% in Group II (P = 0.869) [Table 1]. The rate of AF was much higher in Group II because the most common indication for TEE was for thrombus evaluation for AF rhythm control. Thus, AF was present in 35.4% of patients with a history of stroke and 78.8% of patients without (P < 0.001). As for the presence of PFO, it was present in 45.8% of patients who had a stroke, but only 17.9% in the nonstroke group (P < 0.001). Thrombus was detected by TEE in 5 (10.4%) patients in Group I (n = 48) and 34 patients (15.6%) in Group II (n = 217) (P = 0.500).
An analysis of AF types in Group I showed that paroxysmal AF was present in eight patients, persistent AF in four patients, and chronic AF in five patients [Table 2].
Considering other echo parameters, left ventricular EF was significantly higher in the stroke group (56.9 ± 9.19 vs. 51.9 ± 10.87; P = 0.002). Regarding the end-diastolic volume, left atrial, and right atrial diameter, there was no significant difference between the two groups (P = 0.059, 0.081, and 0.061, respectively) [Table 3].
|Table 3: Comparison of CHA2D2S VASc scores, echocardiographic, and laboratory parameters of patients|
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The CHA2 DS2-VASc score was 3.25 ± 2.06 in Group I and 2.49 ± 1.54 in Group II (P < 0.001).
Beta-blocker use was found to be higher in Group II since the number of patients with AF was correspondingly high. Similarly, oral anticoagulant and antiaggregant use was also significantly higher in Group II. A total of 17 patients were using oral anticoagulants in Group I. Three of them received oral anticoagulation with acetyl salicylic acid combination. Six patients did not receive any treatment. Of the five patients with thrombus, two were using warfarin; two were using acetyl salicylic acid and clopidogrel; and a patient was using acetyl salicylic acid alone [Table 4].
[Figure 1] shows a receiver operating characteristic (ROC) curve for CHA2 DS2-VASc score. According to it, an international normalized ratio (INR) level above 3.5 has a sensitivity of 42% and a specificity of 73% for stroke prediction.
|Figure 1: Receiver operating characteristic curve of CHA2DS2-VASc score Area under curve 0.598 (95% Confidence Interval 0.500-0.696)|
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A univariate regression analysis showed that PFO, CHA2 DS2-VASc category, pulmonary artery pressure, tricuspid insufficiency, diastolic dysfunction, and EF category were significant univariate predictors of stroke. INR level of 3.5 found in the ROC analysis was taken as the cutoff level. EF category was based on the normal EF level of 55%. A multiple regression analysis for the risk factors revealed that PFO, CHA2DS2-VASc category emerged as significant independent predictors of cerebrovascular event [Table 5]. Accordingly, having a PFO increased the cerebrovascular event risk by 4.02 times (95% confidence interval [CI], 1.99–8.11), while a CHA2 DS2-VASc score above 3.5 increased the same risk by 3.52 times (95% CI, 1.64–7.57).
| Discussion|| |
In a study investigating the risk of stroke based on the CHA2 DS2-VASc score, which determines the risk of stroke in AF, Olesen et al. found a 1-year stroke risk of 0.84 for a CHA2 DS2-VASc score of 0 point; 1.79 for 1 point; 3.67 for 2 points; 5.75 for 3 points; and 8.18% for 4 points. Therefore, 2016 European Society of Cardiology AF guideline  assigned a Class I indication for long-term anticoagulation when the CHA2 DS2-VASc score is equal to or >2 for men and equal to or >3 for women, and a Class IIa recommendation for a CHA2 DS2-VASc score of 1 for men and 2 for women. The type of AF is currently not taken into consideration for initiating long-term anticoagulation.
In a study by Paciaroni et al., where 713 patients were compared with 700 controls, patients with CHA2 DS2-VASc score ≥4 were shown to be significantly higher in the patient group (85.1% vs. 45.4%; P = 0.0001). However, that study did not specify average scores. In a multivariate analysis, the CHA2 DS2-VASc score was found to be 1.72 (1.58–1.88).
In a study comparing the CHA2 DS2-VASc scoring system and other scoring systems, the most useful score for determining the risk of stroke was the CHA2 DS2-VASc score, with a score of 2 and above increasing the risk. Accordingly, 2.2% (5/227) of the patient population had a score of 1 (P = 0.27), whereas a score of 2 or above was associated with a thromboembolism rate of 14.67% (333/2300) (P = 0.0005). In our study, the mean CHA2 DS2-VASc score of both groups was above 2, but was found to be 3.25 ± 2.06 in patients with stroke. Studies similar to our study generally recruited patients with AF. However, some authors have advocated that the components of the CHA2 DS2-VASc score are some general thromboembolism risk factors, which are not specific to AF. For this reason, it is considered that patients without AF but higher CHA2 DS2-VASc scores have a higher stroke risk than those with lower CHA2 DS2-VASc scores. Our study data also support this notion. Thus, if a patient has a high CHA2 DS2-VASc score but no AF, he or she may return with cerebrovascular events even within a short period of time. In addition, another study, where coagulation factors related to LAA thrombus were studied, 32 patients with a history of LAA thrombus were compared with 32 controls. Recurrent thromboembolic events were observed in ten patients in the LAA thrombus group and seven patients in the control group. These events were shown to be associated with high thrombin generation, fibrinogen, plasminogen activator inhibitor-1, and soluble CD40 ligand. Since our study is a retrospective study, coagulation factors could not be investigated, but it should be kept in mind that these factors should be screened in patients who do not have any history of AF but have sustained a thrombotic event. In a study  investigated the presence of left atrial thrombus in patients with previous stroke, and found a rate of 5.5% in patients with sinus rhythm. In our study, the rate of thrombus was 10.4% (5/48) in the stroke group. Of these, two patients did not have a history of AF, while the remainder patients had AF. All of five patients were receiving an anticoagulant or antiplatelet.
Our study also detected a significantly higher rate of PFO in the stroke group. PFO is a defect at the interatrial septum, which has been linked with cryptogenic stroke. The presumed mechanism of cryptogenic stroke caused by a PFO is the migration of thrombus from the venous side of the circulation to the left atrium with subsequent systemic embolism, a condition called paradoxical embolization. Provocative maneuvers and preexisting cardiopulmonary disease can cause elevation in right atrial pressures, leading to right-to-left shunting through a PFO. If a patient has cryptogenic stroke and no other risk factor for stroke, the patient should be evaluated for PFO closure. Ozdemir et al. examined the association of obstructive sleep apnea and PFO in two patients with stroke. Increased blood viscosity and platelet aggregation in patients with obstructive sleep apnea were implicated as predisposing conditions for clot formation. In a large patient-based meta-analysis, PFO closure and antiplatelet therapy were shown to provide a significant reduction in ischemic stroke, especially among patients under 60 years of age. In another study by Saver et al., PFO closure in adults with a history of cryptogenic stroke was shown to significantly reduce ischemic stroke compared to medical treatment. These data explain the emergence of PFO as one of the important causes of stroke in our study.
| Conclusions|| |
The CHA2 DS2-VASc score increases the risk of stroke in a broader sense, but not only in patients with AF. It is reasonable to think that the higher the score, the higher the risk of stroke. Furthermore, the presence of PFO in a patient is a facilitating factor for stroke, which may be considered for closure in the case of recurrent stroke episodes.
Our study was a retrospective study, so we had not any data about advanced echocardiographic parameters such as left atrial appendage strain rate. We had less patients with stroke and we did not perform Holter monitoring to exclude paroxysmal AF. We evaluate patients with patient history and clinic electrocardiogram.
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Conflicts of interest
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| References|| |
Ferro JM. Cardioembolic stroke: An update. Lancet Neurol 2003;2:177-88.
Al-Saady NM, Obel OA, Camm AJ. Left atrial appendage: Structure, function, and role in thromboembolism. Heart 1999;82:547-54.
Lip GY, Nieuwlaat R, Pisters R, Lane DA, Crijns HJ. Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach: The euro heart survey on atrial fibrillation. Chest 2010;137:263-72.
Steffel J, Verhamme P, Potpara TS, Albaladejo P, Antz M, Desteghe L, et al
. The 2018 European Heart Rhythm Association Practical Guide on the use of non-Vitamin K antagonist oral anticoagulants in patients with atrial fibrillation. Eur Heart J 2018;39:1330-93.
Overell JR, Bone I, Lees KR. Interatrial septal abnormalities and stroke: A meta-analysis of case-control studies. Neurology 2000;55:1172-9.
Hagen PT, Scholz DG, Edwards WD. Incidence and size of patent foramen ovale during the first 10 decades of life: An autopsy study of 965 normal hearts. Mayo Clin Proc 1984;59:17-20.
Spencer MP, Moehring MA, Jesurum J, Gray WA, Olsen JV, Reisman M. PowerM-mode transcranial Doppler for diagnosis of patent foramen ovale and assessing transcathether closure. J Neuroimaging 2004;14:342-9.
Kirchhof P, Benussi S, Kotecha D, Ahlsson A, Atar D, Casadei B, et al
. ESC Scientific Document Group. 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. Eur Heart J 2016;37:2893-962.
Olesen JB, Torp-Pedersen C, Hansen ML, Lip GY. The value of the CHA2DS2-VASc score for refining stroke risk stratification in patients with atrial fibrillation with a CHADS2 score 0-1: A nationwide cohort study. Thromb Haemost 2012;107:1172-9.
Paciaroni M, Agnelli G, Caso V, Silvestrelli G, Seiffge DJ, Engelter S, et al
. Causes and risk factors of cerebral ischemic events in patients with atrial fibrillation treated with non-Vitamin K antagonist oral anticoagulants for stroke prevention. Stroke 2019;50:2168-74.
Aakre CA, McLeod CJ, Cha SS, Tsang TS, Lip GY, Gersh BJ. Comparison of clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation. Stroke 2014;45:426-31.
Meus R, Son M, Sobczyk D, Undas A. Prothrombotic State in Patients with a left atrial appendage thrombus of unknown origin and cerebrovascular events. Stroke, 2016;47:1872-8.
Yahia AM, Shaukat A, Kirmani JF, Latorre JG, Qureshi Al. Prevalence and prediction of left atrial thrombus in patients with a recent cerebral ishchemic event, who are in sinus rhythm: A single center experience. J NeuroImagıng 2009;19:323-5.
Ozdemir O, Beletsky V, Hachinski V, Spence JD. Cerebrovascular events on awakening, patent foramen ovale and obstructive sleep apnea syndrome. J Neurol Sci 2008;268:193-4.
Saver JL, Carroll JD, Thaler DE, Swalling RW, MacDonald LA, Marks DS, et al
. Long-term outcomes of patent foramen ovale closure or medical therapy after stroke. N Engl J Med 2017;337:1022-32.
[Table 1], [Table 2], [Table 3], [Table 4], [Table 5]