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ORIGINAL ARTICLE
Year : 2021  |  Volume : 7  |  Issue : 2  |  Page : 50-54

A new predictor of in-stent restenosis in patients undergoing elective percutaneous coronary İntervention: triglyceride glucose İndex


1 Department of Cardiology, Haseki Training and Research Hospital, University of Health Science, Istanbul, Turkey
2 Department of Cardiology, Istanbul University-Cerrahpasa Cardiology Institute, Istanbul, Turkey
3 Department of Biochemistry, Istanbul University-Cerrahpasa Cardiology Institute, Istanbul, Turkey
4 Department of Cardiology, Istanbul Training and Research Hospital, University of Health Science, Istanbul, Turkey
5 Department of Cardiology, Private Echomar Hospital, Zonguldak, Turkey

Correspondence Address:
Dr. Muhsin Kalyoncuoglu
Department of Cardiology, Haseki Training and Research Hospital, University of Health Science, Istanbul 34147
Turkey
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijca.ijca_15_21

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Objective: This study aimed to investigate whether triglyceride glucose (TyG) index predicts the development of in-stent restenosis (ISR) in patients undergoing percutaneous coronary intervention (PCI) for de novo lesions. Materials and Methods: This was a prospective case controlled study and includes 124 patients with a mean age of 57 ± 9.1. Control coronary angiography was performed in all patients enrolled in the study 6–12 months after the PCI. Blood sample triglycerides (TGs) and blood glucose concentrations were collected after at least 8 h of fasting. The TyG index was calculated as follows: log (serum TGs [mg/dL] × plasma glucose [mg/dL]/2). The study cohort was divided into two groups as those with and without restenosis. Angiographically, stent restenosis, defined as the presence of ≥50% diameter narrowing either within the stent or within 5 mm proximally or distally to the stent margin. Results: The median follow-up time was 7.17 months (±2.01). Forty-eight patients (38.7%) had restenosis. Patients with ISR had more diabetes (P < 0.01) and CAD (P = 0.03). These also had higher TyG index (P = 0.04) and less drug-eluting stent implantation (P = 0.04). Diabetes (odds ratio [OR]: 1.927, P = 0.03), stent type (OR: 0.342, P = 0.02), and TyG index (OR: 4.144, P = 0.01) significantly predicted ISR. The receiver operating characteristics curve analysis revealed a cutoff value of TyG index >4.71 predicts the development of ISR. Conclusion: A TyG above 4.71 was found a risk factor for ISR during 1-year follow-up period after index elective PCI.


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