International Journal of the Cardiovascular Academy

ORIGINAL ARTICLE
Year
: 2021  |  Volume : 7  |  Issue : 2  |  Page : 50--54

A new predictor of in-stent restenosis in patients undergoing elective percutaneous coronary İntervention: triglyceride glucose İndex


Muhsin Kalyoncuoglu1, Alev Arat Ozkan2, Aysem Kaya3, Yasin Yuksel4, Nafi Dogan5, Aziz Tevfik Gurmen2 
1 Department of Cardiology, Haseki Training and Research Hospital, University of Health Science, Istanbul, Turkey
2 Department of Cardiology, Istanbul University-Cerrahpasa Cardiology Institute, Istanbul, Turkey
3 Department of Biochemistry, Istanbul University-Cerrahpasa Cardiology Institute, Istanbul, Turkey
4 Department of Cardiology, Istanbul Training and Research Hospital, University of Health Science, Istanbul, Turkey
5 Department of Cardiology, Private Echomar Hospital, Zonguldak, Turkey

Correspondence Address:
Dr. Muhsin Kalyoncuoglu
Department of Cardiology, Haseki Training and Research Hospital, University of Health Science, Istanbul 34147
Turkey

Objective: This study aimed to investigate whether triglyceride glucose (TyG) index predicts the development of in-stent restenosis (ISR) in patients undergoing percutaneous coronary intervention (PCI) for de novo lesions. Materials and Methods: This was a prospective case controlled study and includes 124 patients with a mean age of 57 ± 9.1. Control coronary angiography was performed in all patients enrolled in the study 6–12 months after the PCI. Blood sample triglycerides (TGs) and blood glucose concentrations were collected after at least 8 h of fasting. The TyG index was calculated as follows: log (serum TGs [mg/dL] × plasma glucose [mg/dL]/2). The study cohort was divided into two groups as those with and without restenosis. Angiographically, stent restenosis, defined as the presence of ≥50% diameter narrowing either within the stent or within 5 mm proximally or distally to the stent margin. Results: The median follow-up time was 7.17 months (±2.01). Forty-eight patients (38.7%) had restenosis. Patients with ISR had more diabetes (P < 0.01) and CAD (P = 0.03). These also had higher TyG index (P = 0.04) and less drug-eluting stent implantation (P = 0.04). Diabetes (odds ratio [OR]: 1.927, P = 0.03), stent type (OR: 0.342, P = 0.02), and TyG index (OR: 4.144, P = 0.01) significantly predicted ISR. The receiver operating characteristics curve analysis revealed a cutoff value of TyG index >4.71 predicts the development of ISR. Conclusion: A TyG above 4.71 was found a risk factor for ISR during 1-year follow-up period after index elective PCI.


How to cite this article:
Kalyoncuoglu M, Ozkan AA, Kaya A, Yuksel Y, Dogan N, Gurmen AT. A new predictor of in-stent restenosis in patients undergoing elective percutaneous coronary İntervention: triglyceride glucose İndex.Int J Cardiovasc Acad 2021;7:50-54


How to cite this URL:
Kalyoncuoglu M, Ozkan AA, Kaya A, Yuksel Y, Dogan N, Gurmen AT. A new predictor of in-stent restenosis in patients undergoing elective percutaneous coronary İntervention: triglyceride glucose İndex. Int J Cardiovasc Acad [serial online] 2021 [cited 2021 Sep 22 ];7:50-54
Available from: https://www.ijcva.com/article.asp?issn=2405-8181;year=2021;volume=7;issue=2;spage=50;epage=54;aulast=Kalyoncuoglu;type=0